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KMID : 0882420100790040432
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Korean Journal of Medicine
2010 Volume.79 No. 4 p.432 ~ p.437
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A case of breast cancer in a patient with multiple endocrine neoplasia type 2
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Roh Jung-Min
Lee Yoon-Bum
An Hye-Rim
Shim Woo-Ho
Lee Eun-Hae
Hong Soon-Won
Cho Min-Ho
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Abstract
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Multiple Endocrine Neoplasia Type 2 (MEN2) is a rare hereditary complex disorder characterized by the presence of medullary thyroid carcinoma, pheochromocytoma, and other hyperplasias or neoplasias of different endocrine tissues within a single patient. Simultaneous occurrence of MEN2 and other cancers that are derived from different origins is rare. In this report, we present a patient with known MEN2 who developed breast cancer as a result of invasive ductal carcinoma. The patient underwent total thyroidectomy and unilateral adrenalectomy due to medullary thyroid cancer and pheochromocytoma. Although patients with MEN2 may demonstrate a variety of neoplastic disorders, it is difficult to identify a case report of MEN2 with breast cancer. In addition, no etiological relationships between breast cancer and MEN2 have been reported to date. Thus, here we report a case of known MEN2 with breast cancer and present a review of the literature.
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KEYWORD
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Breast cancer, Multiple endocrine neoplasia type 2, Proto-oncogene protein RET
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